Primary Identifier | MGI:2388707 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 268379 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Involved in ceramide transport; positive regulation of cholesterol transport; and positive regulation of synaptic vesicle endocytosis. Located in intracellular vesicle. Is expressed in bone marrow; genitourinary system; and retina. Human ortholog(s) of this gene implicated in gastric adenocarcinoma. Orthologous to human ABCA13 (ATP binding cassette subfamily A member 13). PHENOTYPE: Mice homozygous for a null allele exhibit reduced prepulse inhibition and vesicular cholesterol accumulation and synaptic vesicle endocytosis are impaired in primary cortical neurons. [provided by MGI curators] |