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Protein Coding Gene : Abca13 ATP-binding cassette, sub-family A member 13

Primary Identifier  MGI:2388707 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  268379
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Involved in ceramide transport; positive regulation of cholesterol transport; and positive regulation of synaptic vesicle endocytosis. Located in intracellular vesicle. Is expressed in bone marrow; genitourinary system; and retina. Human ortholog(s) of this gene implicated in gastric adenocarcinoma. Orthologous to human ABCA13 (ATP binding cassette subfamily A member 13).
PHENOTYPE: Mice homozygous for a null allele exhibit reduced prepulse inhibition and vesicular cholesterol accumulation and synaptic vesicle endocytosis are impaired in primary cortical neurons. [provided by MGI curators]
  • synonyms:
  • ATP-binding cassette, sub-family A member 13,
  • AI956815,
  • Abca13,
  • RIKEN cDNA A930002G16 gene,
  • expressed sequence AI956815,
  • MGI:2144330,
  • A930002G16Rik

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Genome

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

3 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

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Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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