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Publication : PIPPing on AKT1: How Many Phosphatases Does It Take to Turn off PI3K?

First Author  Toker A Year  2015
Journal  Cancer Cell Volume  28
Issue  2 Pages  143-5
PubMed ID  26267528 Mgi Jnum  J:224917
Mgi Id  MGI:5689751 Doi  10.1016/j.ccell.2015.07.010
Citation  Toker A, et al. (2015) PIPPing on AKT1: How Many Phosphatases Does It Take to Turn off PI3K?. Cancer Cell 28(2):143-5
abstractText  In this issue of Cancer Cell, Ooms and colleagues show that the lipid phosphatase PIPP/INPP5J, frequently inactivated in triple-negative breast cancers, functions as a tumor suppressor by specifically modulating the activity of AKT1 in the context of oncogenic PI3K signaling, leading to inhibition of metastatic dissemination.
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