| First Author | Johannes GJ | Year | 1993 |
| Journal | J Mol Evol | Volume | 36 |
| Issue | 6 | Pages | 555-67 |
| PubMed ID | 8350350 | Mgi Jnum | J:33285 |
| Mgi Id | MGI:80765 | Doi | 10.1007/BF00556360 |
| Citation | Johannes GJ, et al. (1993) Domains within the mammalian ornithine decarboxylase messenger RNA have evolved independently and episodically. J Mol Evol 36(6):555-67 |
| abstractText | Ornithine decarboxylase (ODC) is the first enzyme in the polyamine biosynthetic pathway. We have studied the evolutionary history of the mammalian ODC mRNA, focusing on the rate of accumulation of sequence divergence within specific subregions of the molecule. The phylogenetic relationships among the mRNAs from several mammalian species, including two mouse species, rat, hamster, and human, were determined based upon the numbers of synonymous substitutions in pairwise comparisons of mRNA coding regions. The separation times for the mRNAs were very similar to those for the corresponding species, suggesting that ODC is encoded by orthologous genes in the different species. Analysis of divergence patterns in four subregions, or domains, of the mRNA (the 5'-untranslated region, the coding region, and two domains of the 3'-untranslated region) showed that the domains have evolved in a noncoordinate fashion. Furthermore, evolution of each subregion has been episodic, with periods of both rapid and slow sequence divergence. We suggest that the episodic pattern of ODC mRNA evolution may indicate the existence of selection pressures that were exerted in a time- and domain-specific manner during mammalian speciation. |
