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Publication : Differential transcription and expression of ornithine decarboxylase in embryos of replicated mouse lines divergently selected for lean body mass.

First Author  Gray A Year  1995
Journal  Biochem J Volume  308 ( Pt 1)
Pages  161-6 PubMed ID  7755561
Mgi Jnum  J:26653 Mgi Id  MGI:74086
Doi  10.1042/bj3080161 Citation  Gray A, et al. (1995) Differential transcription and expression of ornithine decarboxylase in embryos of replicated mouse lines divergently selected for lean body mass. Biochem J 308(Pt 1):161-6
abstractText  Embryos of replicated mouse lines divergently selected for high or low lean body mass have been shown to differ approximately twofold in the activity of ornithine decarboxylase during embryogenesis and that this difference has been shown to be associated with a restriction enzyme polymorphism in the structural gene [Gray and Tait (1993) Genet. Res. 62, 31-37]. In the present paper we report that the differences in enzyme activity are due to changes in transcription and show that the enzyme produced has the same specific activity in all selected lines, precluding any significant structural change in the enzyme being associated with the differences in the structural gene.
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