Primary Identifier | MGI:6466717 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Adamts17 |
Transmission | Germline | Strain of Origin | Not Specified |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A loxP site was inserted upstream of exon 4, and an FRT-flanked neomycin selection cassette and a second loxP site were inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette and cre-mediated recombination in the germline deleted exon 4. Deletion of exon 4 generates a frame-shift leading to disruption of the zinc-dependent metalloprotease domain and its downstream sequences. |