| First Author | van der Houven van Oordt CW | Year | 1999 |
| Journal | Genes Chromosomes Cancer | Volume | 24 |
| Issue | 3 | Pages | 191-8 |
| PubMed ID | 10451698 | Mgi Jnum | J:52560 |
| Mgi Id | MGI:1329759 | Doi | 10.1002/(sici)1098-2264(199903)24:3<191::aid-gcc3>3.0.co;2-l |
| Citation | van der Houven van Oordt CW, et al. (1999) The genetic background modifies the spontaneous and X-ray-induced tumor spectrum in the Apc1638N mouse model. Genes Chromosomes Cancer 24(3):191-8 |
| abstractText | The effect of the genetic background on the tumor spectrum of Apc1638N, a mouse model for attenuated familial adenomatous polyposis (FAP), has been investigated in X-irradiated and untreated F1 hybrids between C57BL/6JIco-Apc1638N (B6) and A/JCrIBR (A/J), BALB/cByJIco (C) or C3H/HeOuJIco (C3). Similar to the ApcMin model, the Apc1638N intestinal tumor multiplicity seems to be modulated by Mom1. Moreover, several additional (X-ray-responsive) modifier loci appear also to affect the Apc1638N intestinal tumor number. The genetic background did not significantly influence the number of spontaneous desmoids and cutaneous cysts in Apc1638N. In general, X-irradiation increased the desmoid multiplicity in Apc1638N females but had no effect in males. The opposite was noted for the cyst multiplicity after X-rays. Surprisingly, X-irradiated CB6F1-Apc1638N females were highly susceptible to the development of ovarian tumors, which displayed clear loss of the wild-type Apc allele. |
