| First Author | Raya A | Year | 2003 |
| Journal | Genes Dev | Volume | 17 |
| Issue | 10 | Pages | 1213-8 |
| PubMed ID | 12730123 | Mgi Jnum | J:83387 |
| Mgi Id | MGI:2661340 | Doi | 10.1101/gad.1084403 |
| Citation | Raya A, et al. (2003) Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos. Genes Dev 17(10):1213-8 |
| abstractText | Left-sided expression of Nodal in the lateral plate mesoderm is a conserved feature necessary for the establishment of normal left-right asymmetry during vertebrate embryogenesis. By using gain- and loss-of-function experiments in zebrafish and mouse, we show that the activity of the Notch pathway is necessary and sufficient for Nodal expression around the node, and for proper left-right determination. We identify Notch-responsive elements in the Nodal promoter, and unveil a direct relationship between Notch activity and Nodal expression around the node. Our findings provide evidence for a mechanism involving Notch activity that translates an initial symmetry-breaking event into asymmetric gene expression. |
