| First Author | Fullerton J | Year | 2006 |
| Journal | Behav Genet | Volume | 36 |
| Issue | 1 | Pages | 147-61 |
| PubMed ID | 16365832 | Mgi Jnum | J:109577 |
| Mgi Id | MGI:3629320 | Doi | 10.1007/s10519-005-9000-4 |
| Citation | Fullerton J (2006) New approaches to the genetic analysis of neuroticism and anxiety. Behav Genet 36(1):147-61 |
| abstractText | The completion of the human genome project and the complementary genome projects for other species has broadened the scope for novel bioinformatic approaches to quantitative trait locus (QTL) identification. A key issue for quantitative trait nucleotide (QTN) identification is progressing from a large QTL peak, spanning perhaps 50 cM and many hundreds of genes, to a gene or nucleotide variant which is responsible for that QTL effect. The complementary use of mouse models to dissect large syntenic loci in humans is a powerful method for reducing QTL intervals to the order of 1 Mb. This paper presents an overview of the approaches used in our laboratory to ultra-fine map QTLs for anxiety-related traits, and to identify quantitative trait genes (QTG). As new genetic techniques and statistical approaches arise, we are getting closer to identifying those long sought after QTNs. |
