| First Author | Efeyan A | Year | 2007 |
| Journal | Oncogene | Volume | 26 |
| Issue | 11 | Pages | 1645-9 |
| PubMed ID | 16964282 | Mgi Jnum | J:121066 |
| Mgi Id | MGI:3709204 | Doi | 10.1038/sj.onc.1209972 |
| Citation | Efeyan A, et al. (2007) Genetic dissection of the role of p21Cip1/Waf1 in p53-mediated tumour suppression. Oncogene 26(11):1645-9 |
| abstractText | Protein p21Cip1/Waf1 is transcriptionally activated by the tumour suppressor p53 and previous studies have shown that p21 plays a role in tumour suppression. However, the involvement of p21 in p53-mediated tumour suppression remains to be directly demonstrated in vivo. Tumour suppression mediated by p53 can be measured by comparing tumour susceptibility in animals carrying two (wild-type mice) or three (super-p53 mice) copies of the p53 gene. We have taken advantage of this genetically defined system to measure p53-mediated cell-cycle arrest, apoptosis and tumorigenesis, in a p21 wild-type and in a p21-null context. The absence of p21 significantly impaired the enhanced p53-mediated cell-cycle arrest characteristic of super-p53 cells, but did not affect the enhanced apoptosis. Importantly, in an experimental model of fibrosarcoma induction, the absence of p21 significantly decreased the tumour suppression benefit of super-p53 mice. We conclude that cell-cycle arrest through p21 plays a significant role in mediating p53-dependent cancer protection. |
