| First Author | Lyngsø C | Year | 2000 |
| Journal | J Biol Chem | Volume | 275 |
| Issue | 34 | Pages | 26144-9 |
| PubMed ID | 10849425 | Mgi Jnum | J:63997 |
| Mgi Id | MGI:1888582 | Doi | 10.1074/jbc.M003405200 |
| Citation | Lyngso C, et al. (2000) Interaction between the transcription factor SPBP and the positive cofactor RNF4. An interplay between protein binding zinc fingers. J Biol Chem 275(34):26144-9 |
| abstractText | The activator of stromelysin 1 gene transcription, SPBP, interacts with the RING finger protein RNF4. Both proteins are ubiquitously expressed and localized in the nucleus. RNF4 facilitates accumulation of specific SPBP-DNA complexes in vitro and acts as a positive cofactor in SPBP-mediated transactivation. SPBP harbors an internal zinc finger of the PHD/LAP type. This domain can form intra-chain protein-protein contacts in SPBP resulting in negative modulation of SPBP-RNF4 interaction. |
