| First Author | Lee H | Year | 2005 |
| Journal | J Neurosci | Volume | 25 |
| Issue | 5 | Pages | 1304-10 |
| PubMed ID | 15689568 | Mgi Jnum | J:98104 |
| Mgi Id | MGI:3577149 | Doi | 10.1523/JNEUROSCI.4745.04.2005 |
| Citation | Lee H, et al. (2005) Altered thermal selection behavior in mice lacking transient receptor potential vanilloid 4. J Neurosci 25(5):1304-10 |
| abstractText | Transient receptor potential vanilloid 4 (TRPV4), a cation channel responsive to hypotonicity, can also be activated by warm temperatures. Moreover, TRPV4-/- mice reportedly exhibit deficits in inflammation-induced thermal hyperalgesia. However, it is unknown whether TRPV4 or related transient receptor potential channels account for warmth perception under injury-free conditions. We therefore investigated the contribution of TRPV4 to thermosensation and thermoregulation in vivo. On a thermal gradient, TRPV4-/- mice selected warmer floor temperatures than wild-type littermates. In addition, whereas wild-type mice failed to discriminate between floor temperatures of 30 and 34 degrees C, TRPV4-/- mice exhibited a strong preference for 34 degrees C. TRPV4-/- mice also exhibited prolonged withdrawal latencies during acute tail heating. TRPV4-/- and wild-type mice exhibited similar changes in behavior on a thermal gradient after paw inflammation. Circadian body temperature fluctuations and thermoregulation in a warm environment were also indistinguishable between genotypes. These results demonstrate that TRPV4 is required for normal thermal responsiveness in vivo. |
