| First Author | Koike S | Year | 2013 |
| Journal | FEBS Lett | Volume | 587 |
| Issue | 21 | Pages | 3548-55 |
| PubMed ID | 24055470 | Mgi Jnum | J:202320 |
| Mgi Id | MGI:5518484 | Doi | 10.1016/j.febslet.2013.09.013 |
| Citation | Koike S, et al. (2013) Polysulfide exerts a protective effect against cytotoxicity caused by t-buthylhydroperoxide through Nrf2 signaling in neuroblastoma cells. FEBS Lett 587(21):3548-55 |
| abstractText | Polysulfide is a bound sulfur species derived from endogenous H2S. When mouse neuroblastoma, Neuro2A cells were exposed to tert-butyl hydroperoxide after treatment with polysulfide, a significant decline in cell toxicity was observed. Rapid uptake of polysulfides induced translocation of Nrf2 into the nucleus, resulting in acceleration of GSH synthesis and HO-1 expression. We demonstrated that polysulfide reversibly modified Keap1 to form oxidized dimers and induced the translocation of Nrf2. Moreover, polysulfide treatment accelerated Akt phosphorylation, which is a known pathway of Nrf2 phosphorylation. Thus, polysulfide may mediate the activation of Nrf2 signaling, thereby exerting protective effects against oxidative damage in Neuro2A cells. |
