| Primary Identifier | IPR037564 | Type | Family |
| Short Name | Complement_C7 |
| description | This entry represents complement component C7, a subunit of the membrane attack complex (MAC) which forms pores in the membranes of cells of invading organisms. C7 anchors the MAC to the membrane. MAC forms when C5 is cleaved into C5a and C5b, and C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9 []. The structure of C7 has been solved and C7 contains a several domains, which from N to C terminus are: TSP type-1, LDL-receptor class A, MACPF, EGF-like, another TSP type-1 and two sushi domains []. Variants of C7 are associated with immunodeficiency diseases and susceptibility to infection such as meningococcal disease caused by Neisseria meningitidis []. |
