| First Author | Lillehaug S | Year | 2014 |
| Journal | Neurobiol Aging | Volume | 35 |
| Issue | 3 | Pages | 556-64 |
| PubMed ID | 24126157 | Mgi Jnum | J:212602 |
| Mgi Id | MGI:5581871 | Doi | 10.1016/j.neurobiolaging.2013.09.013 |
| Citation | Lillehaug S, et al. (2014) Brainwide distribution and variance of amyloid-beta deposits in tg-ArcSwe mice. Neurobiol Aging 35(3):556-64 |
| abstractText | Transgenic mice carrying the Arctic (E693G) and Swedish (KM670/6701NL) amyloid-beta precursor protein (AbetaPP) develop amyloid-beta (Abeta) deposits in the brain that resemble Alzheimer's disease neuropathology. Earlier studies of this model have documented morphologic features in selected parts of the cerebral cortex and hippocampus, but the spatial distribution within the brain and variance of Abeta deposits within a group of tg-ArcSwe mice is unknown. Using immunohistochemistry and brainwide microscopic analysis of 12-month-old tg-ArcSwe mice, we show that Abetax-40 plaque deposits are consistently present in the cerebral cortex, hippocampus, and thalamus and variably present in other regions. Using quantitative image analysis, we demonstrated that the average Abeta burden in the cortex and hippocampus is similar across animals, with coefficients of variance of 22% and 25%, respectively. This indicates that interventional studies of tg-ArcSwe mice are feasible using region-of-interest comparisons and that interventional trials require larger group sizes than commonly used. We also present an online atlas providing access to images showing the detailed characteristics and spatial distribution patterns of Abetax-40 labeling. |
