First Author | Cheng JG | Year | 2003 |
Journal | Biol Reprod | Volume | 68 |
Issue | 2 | Pages | 401-4 |
PubMed ID | 12533402 | Mgi Jnum | J:81389 |
Mgi Id | MGI:2449240 | Doi | 10.1095/biolreprod.102.009589 |
Citation | Cheng JG, et al. (2003) Loss of cyclooxygenase-2 retards decidual growth but does not inhibit embryo implantation or development to term. Biol Reprod 68(2):401-4 |
abstractText | Previous reports have described that female mice deficient in cyclooxygenase-2 (COX2) are largely infertile because of failure to ovulate, poor fertilization, and defective implantation and decidualization. In the present study, we reinvestigated reproduction in these mice and found they do show a reduction in the numbers of ovulated and fertilized eggs. However, we did not observe any substantial effect on embryo implantation frequencies or an inability of COX2-deficient females to support embryo development to weaning. Pseudopregnant COX2-null recipients do not show any alteration in the timing of implantation following blastocyst transfer, but they do show a delay in the initial rate of decidual growth after implantation that lags by approximately 24 h compared to that in heterozygous or wild-type recipients. These results support previous findings that COX2 has a role in mediating the initial uterine decidual response but is not essential to sustaining decidual growth and embryo development throughout the remainder of pregnancy. |