Primary Identifier | MGI:2181794 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Ryr3 |
Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Exon 6 was replaced with a neomycin resistance gene via homologous recombination resulting in the deletion of the transmembrane domain containing carboxy terminus of the protein. Western blot analysis of microsomal proteins from diaphram muscles confirmed the absence of gene expression in homozygous mutant animals. |