| First Author | Ambroggi F | Year | 2009 |
| Journal | Nat Neurosci | Volume | 12 |
| Issue | 3 | Pages | 247-9 |
| PubMed ID | 19234455 | Mgi Jnum | J:150544 |
| Mgi Id | MGI:3850930 | Doi | 10.1038/nn.2282 |
| Citation | Ambroggi F, et al. (2009) Stress and addiction: glucocorticoid receptor in dopaminoceptive neurons facilitates cocaine seeking. Nat Neurosci 12(3):247-9 |
| abstractText | The glucocorticoid receptor is a ubiquitous transcription factor mediating adaptation to environmental challenges and stress. Selective Nr3c1 (the glucocorticoid receptor gene) ablation in mouse dopaminoceptive neurons expressing dopamine receptor 1a, but not in dopamine-releasing neurons, markedly decreased the motivation of mice to self-administer cocaine, dopamine cell firing and the control exerted by dopaminoceptive neurons on dopamine cell firing activity. In contrast, anxiety was unaffected, indicating that glucocorticoid receptors modify a number of behavioral disorders through different neuronal populations. |
