| Primary Identifier | MGI:2152961 | Allele Type | Targeted |
| Gene | Ntf3 | Transmission | Germline |
| Strain of Origin | 129S1/Sv-Oca2<+> Tyr<+> Kitl<+> | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Sequences encoding the BDNF protein replaced the entire coding region of the Ntf3 gene. A loxP flanked neomycin cassette was inserted adjacent to the coding region of the gene, but was removed via cre-mediated recombination in the final allele. Northern blot analysis and in situ hybridization analysis confirmed expression of a Bdnf transcript from this allele that mimicked the expression pattern of the endogenous Ntf3. |
