| First Author | Naramura M | Year | 2002 |
| Journal | Nat Immunol | Volume | 3 |
| Issue | 12 | Pages | 1192-9 |
| PubMed ID | 12415267 | Mgi Jnum | J:80427 |
| Mgi Id | MGI:2445859 | Doi | 10.1038/ni855 |
| Citation | Naramura M, et al. (2002) c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation. Nat Immunol 3(12):1192-9 |
| abstractText | How Cbl family proteins regulate T cell responses is unclear. We found that c-Cbl Cbl-b double knock-out (dKO) T cells became hyperresponsive upon anti-CD3 stimulation, even though the major T cell antigen receptor (TCR) signaling pathways were not enhanced. The dKO T cells did not down-modulate surface TCR after ligand engagement, which resulted in sustained TCR signaling. However, these cells showed normal ligand-independent TCR internalization, and trafficking of internalized TCR to the lysosome compartment after ligand engagement was reduced. These findings show that Cbl family proteins negatively regulate T cell activation by promoting clearance of engaged TCR from the cell surface, a process that is apparently essential for the termination of TCR signals. |
