| First Author | Dodd RD | Year | 2016 |
| Journal | Oncogene | Volume | 35 |
| Issue | 14 | Pages | 1868-75 |
| PubMed ID | 26234681 | Mgi Jnum | J:234210 |
| Mgi Id | MGI:5789492 | Doi | 10.1038/onc.2015.252 |
| Citation | Dodd RD, et al. (2016) Myogenic transcription factors regulate pro-metastatic miR-182. Oncogene 35(14):1868-75 |
| abstractText | Approximately 30% of patients with soft-tissue sarcoma die from pulmonary metastases. The mechanisms that drive sarcoma metastasis are not well understood. Recently, we identified miR-182 as a driver of sarcoma metastasis in a primary mouse model of soft-tissue sarcoma. We also observed elevated miR-182 in a subset of primary human sarcomas that metastasized to the lungs. Here, we show that myogenic differentiation factors regulate miR-182 levels to contribute to metastasis in mouse models. We find that MyoD directly binds the miR-182 promoter to increase miR-182 expression. Furthermore, mechanistic studies revealed that Pax7 can promote sarcoma metastasis in vivo through MyoD-dependent regulation of pro-metastatic miR-182. Taken together, these results suggest that sarcoma metastasis can be partially controlled through Pax7/MyoD-dependent activation of miR-182 and provide insight into the role that myogenic transcription factors have in sarcoma progression. |
