| First Author | Fukui Y | Year | 2007 |
| Journal | Biochem Biophys Res Commun | Volume | 356 |
| Issue | 2 | Pages | 512-6 |
| PubMed ID | 17367752 | Mgi Jnum | J:121437 |
| Mgi Id | MGI:3710043 | Doi | 10.1016/j.bbrc.2007.03.011 |
| Citation | Fukui Y, et al. (2007) SWAP-70 is required for oncogenic transformation by v-Src in mouse embryo fibroblasts. Biochem Biophys Res Commun 356(2):512-6 |
| abstractText | SWAP-70 is a phosphatidylinositol trisphosphate (PtdIns(3,4,5)P(3)) binding protein, which acts in F-actin rearrangement. The role of SWAP-70 in oncogenic transformation of mouse embryo fibroblasts (MEFs) by v-Src was examined by use of MEFs defective in SWAP-70. v-Src morphologically transformed MEFs lacking SWAP-70, but growth of the transformed cells in culture was slower than that of cells supplemented with exogenous SWAP-70. The v-Src-transformed MEFs deficient in SWAP-70 were unable to grow in soft agar while those expressing SWAP70 readily formed colonies, suggesting that SWAP-70 is required for anchorage independent growth of v-Src transformed MEFs. When transplanted in nude mice, tumors formed by the v-Src transformed SWAP-70(-/-) MEFs were smaller than those formed by cells expressing exogenous SWAP-70. These results suggest that SWAP-70 may be required for oncogenic transformation and contributes to cell growth in MEFs transformed by v-Src. |
