| First Author | Hoang T | Year | 2010 |
| Journal | Sci Transl Med | Volume | 2 |
| Issue | 21 | Pages | 21ps10 |
| PubMed ID | 20374994 | Mgi Jnum | J:167882 |
| Mgi Id | MGI:4880845 | Doi | 10.1126/scitranslmed.3000885 |
| Citation | Hoang T (2010) Of mice and men: how an oncogene transgresses the limits and predisposes to T cell acute lymphoblastic leukemia. Sci Transl Med 2(21):21ps10 |
| abstractText | The gene encoding LIM-only 2 (LMO2), an oncogenic transcription factor, is frequently activated in T cell acute lymphoblastic leukemia (T-ALL), but how LMO2 transforms primary hematopoietic cells to induce T-ALL remains an open question. McCormack et al. now show that, in mice, Lmo2 confers self-renewal potential on normally nonrenewing thymocyte progenitor cells, and this property is maintained over four serial transplantations when the cells are transplanted into irradiated mice that lack thymocytes. These leukemia-initiating cells are resistant to irradiation, indicating the need to develop new therapeutic drugs that specifically target the oncogene itself. |
