| Primary Identifier | IPR031364 | Type | Family |
| Short Name | GC_assoc_lym |
| description | HGAL (human germinal centre-associated lymphoma, also known as a germinal centre-expressed transcript 2 or germinal centre-associated signalling and motility protein) is part of a family of mammalian sequences typically between 104 and 179 amino acids in length. Members were discovered in a search for proteins precipitating diffuse large B-cell lymphomas [, ]. HGAL and its murine homologue, M17 protein, are specifically expressed in germinal centre (GC) B-lymphocytes [].HGAL interacts with the cytoskeleton and aids the activity of interleukin-6 on cell migration []. It also modulates the RhoA signalling pathway []. HGAL protein also regulates B-cell receptor (BCR) signalling []. It seems that membrane-bound and cytoplasmic HGAL regulates distinct biological processes in B-cells. |
