| Primary Identifier | IPR037853 | Type | Domain |
| Short Name | Net1_PH |
| description | Net1 (also called ArhGEF8) is a RhoA-specific GEF (guanine nucleotide exchange factors). Net1 binds to caspase activation and recruitment domain (CARD)- and membrane-associated guanylate kinase-like domain-containing (CARMA) proteins and regulates nuclear factor kB activation []. In nucleus, it also regulates RhoB-mediated cell death after DNA damage []. Net1 and RhoA have been shown to play important roles in various aspects of vertebrate embryonic development and organogenesis [].Net1 contains a catalytic Dbl homology (DH) domain and an adjacent pleckstrin homology (PH) domain flanked by N- and C-terminal extensions []. This entry represents the PH domain. The DH and PH domains are necessary for binding to the GTPase and stimulating nucleotide exchange activity []. |
