| First Author | Harly C | Year | 2019 |
| Journal | Nat Immunol | Volume | 20 |
| Issue | 9 | Pages | 1150-1160 |
| PubMed ID | 31358996 | Mgi Jnum | J:306903 |
| Mgi Id | MGI:6706728 | Doi | 10.1038/s41590-019-0445-7 |
| Citation | Harly C, et al. (2019) The transcription factor TCF-1 enforces commitment to the innate lymphoid cell lineage. Nat Immunol 20(9):1150-1160 |
| abstractText | Innate lymphoid cells (ILCs) play important functions in immunity and tissue homeostasis, but their development is poorly understood. Through the use of single-cell approaches, we examined the transcriptional and functional heterogeneity of ILC progenitors, and studied the precursor-product relationships that link the subsets identified. This analysis identified two successive stages of ILC development within T cell factor 1-positive (TCF-1(+)) early innate lymphoid progenitors (EILPs), which we named 'specified EILPs' and 'committed EILPs'. Specified EILPs generated dendritic cells, whereas this potential was greatly decreased in committed EILPs. TCF-1 was dispensable for the generation of specified EILPs, but required for the generation of committed EILPs. TCF-1 used a pre-existing regulatory landscape established in upstream lymphoid precursors to bind chromatin in EILPs. Our results provide insight into the mechanisms by which TCF-1 promotes developmental progression of ILC precursors, while constraining their dendritic cell lineage potential and enforcing commitment to ILC fate. |
