| Primary Identifier | MGI:1338069 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 16443 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.4.0) Enables kinase activator activity. Involved in synaptic vesicle endocytosis. Acts upstream of or within negative regulation of neuron apoptotic process; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and small GTPase-mediated signal transduction. Located in clathrin-coated pit; endocytic vesicle; and lamellipodium. Is active in calyx of Held and presynaptic endocytic zone. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Orthologous to human ITSN1 (intersectin 1). PHENOTYPE: Homozygous for a gene trapped allele exhibit embryonic lethal. Mice homozygous for a null allele exhibit some postnatal lethality and impaired vesicle recycling in surviving mice. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
