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Allele : Dnase2a<tm1Aea> deoxyribonuclease II alpha; targeted mutation 1, Alan Eastman
Primary Identifier  MGI:3040926 Allele Type  Targeted
Attribute String  Null/knockout Gene  Dnase2a
Transmission  Germline Strain of Origin  129
Is Recombinase  false Is Wild Type  false
molecularNote  The first five exons were replaced with a PGK-neomycin resistance gene via homologous recombination. The genetic disruption resulted in complete loss of acid endonuclease activity in mouse embryonic fibroblasts and E15.5 livers from homozygous mutant embryos.
  • mutations:
  • Insertion,
  • Intragenic deletion
  • synonyms:
  • DNase IIalpha -,
  • DNase IIalpha -
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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