| First Author | Göttgens B | Year | 1998 |
| Journal | Genomics | Volume | 48 |
| Issue | 1 | Pages | 52-62 |
| PubMed ID | 9503016 | Mgi Jnum | J:46273 |
| Mgi Id | MGI:1197439 | Doi | 10.1006/geno.1997.5162 |
| Citation | Gottgens B, et al. (1998) The pufferfish SLP-1 gene, a new member of the SCL/TAL-1 family of transcription factors. Genomics 48(1):52-62 |
| abstractText | The SCL/TAL-1 gene encodes a basic helix-loop-helix (bHLH) transcription factor essential for the development of all hemopoietic lineages and also acts as a T-cell oncogene. Four related genes have been described in mammals (LYL-1, TAL-2, NSCL1, and NSCL2), all of which exhibit a high degree of sequence similarity to SCL/TAL-1 in the bHLH domain and two of which (LYL-1 and TAL-2) have also been implicated in the pathogenesis of T-cell acute lymphoblastic leukemia. In this study we describe the identification and characterization of a pufferfish gene termed SLP-1, which represents a new member of this gene family. The genomic structure and sequence of SLP-1 suggests that it forms a subfamily with SCL/TAL-1 and LYL-1 and is most closely related to SCL/TAL-1. However, unlike SCL/TAL-1, SLP-1 is widely expressed. Sequence analysis of a whole cosmid containing SLP-1 shows that SLP-1 is flanked upstream by a zinc finger gene and a fork-head-domain gene and downstream by a heme-oxygenase and a RING finger gene. |
