| First Author | Dalasanur Nagaprashantha L | Year | 2017 |
| Journal | Int J Cancer | PubMed ID | 28975625 |
| Mgi Jnum | J:248082 | Mgi Id | MGI:5926538 |
| Doi | 10.1002/ijc.31085 | Citation | Dalasanur Nagaprashantha L, et al. (2018) Translational opportunities for broad-spectrum natural phytochemicals and targeted agent combinations in breast cancer. Int J Cancer 142(4):658-670 |
| abstractText | Breast cancer (BC) prevention and therapy in the context of life-style risk factors and biological drivers is a major focus of developmental therapeutics in oncology. Obesity, alcohol, chronic estrogen signaling and smoking have distinct BC precipitating and facilitating effects that may act alone or in combination. A spectrum of signaling events including enhanced oxidative stress and changes in estrogen-receptor (ER)-dependent and -independent signaling drive the progression of BC. Breast tumors modulate ERalpha/ERbeta ratio, upregulate proliferative pathways driven by ERalpha and HER2 with a parallel loss and/or downregulation of tumor suppressors such as TP53 and PTEN which together impact the efficacy of therapeutic strategies and frequently lead to emergence of drug resistance. Natural phytochemicals modulate oxidative stress, leptin, integrin, HER2, MAPK, ERK, Wnt/beta-catenin and NFkappaB signaling along with regulating ERalpha and ERbeta, thereby presenting unique opportunities for both primary and combinatorial interventions in BC. In this regard, this article focuses on critical analyses of the evidence from multiple studies on the efficacy of natural phytochemicals in BC. In addition, areas in which the combinations of such effective natural phytochemicals with approved and/or developing anticancer agents can be translationally beneficial are discussed to derive evidence-based inference for addressing challenges in BC control and therapy. |
