| First Author | Scott AL | Year | 2008 |
| Journal | Neuroreport | Volume | 19 |
| Issue | 7 | Pages | 739-43 |
| PubMed ID | 18418249 | Mgi Jnum | J:136818 |
| Mgi Id | MGI:3797164 | Doi | 10.1097/WNR.0b013e3282fd6e88 |
| Citation | Scott AL, et al. (2008) Novel monoamine oxidase A knock out mice with human-like spontaneous mutation. Neuroreport 19(7):739-43 |
| abstractText | A novel line of mutant mice [monoamine oxidase A knockout (MAOA KO)] harboring a spontaneous point nonsense mutation in exon 8 of the MAO A gene was serendipitously identified in a 129/SvEvTac colony. This mutation is analogous to the cause of a rare human disorder, Brunner syndrome, characterized by complete MAO A deficiency and impulsive aggressiveness. Concurrent with previous studies of MAO A KO mice generated by insertional mutagenesis ('Tg8'), MAOA(A863T) KO lack MAO A enzyme activity and display enhanced aggression toward intruder mice. MAOA(A863T) KO, however, exhibited lower locomotor activity in a novel, inescapable open field and similar immobility during tail suspension compared with wild type, observations which differ from reports of Tg8. These findings consolidate evidence linking MAO A to aggression and highlight subtle yet distinctive phenotypical characteristics. |
