| First Author | Moreau PH | Year | 2013 |
| Journal | Behav Brain Res | Volume | 243 |
| Pages | 1-5 | PubMed ID | 23291160 |
| Mgi Jnum | J:197161 | Mgi Id | MGI:5490948 |
| Doi | 10.1016/j.bbr.2012.12.043 | Citation | Moreau PH, et al. (2013) ApoE4 confers better spatial memory than apoE3 in young adult hAPP-Yac/apoE-TR mice. Behav Brain Res 243:1-5 |
| abstractText | The APOE-varepsilon4 allele is associated with increased cognitive decline during normal aging and Alzheimer's disease. However, several studies intriguingly found a beneficial effect on cognition in young adult human APOE-varepsilon4 carriers. Here, we show that 3-month old bigenic hAPP-Yac/apoE4-TR mice outperformed their hAPP-Yac/apoE3-TR counterparts on learning and memory performances in the highly hippocampus-dependent, hidden-platform version of the Morris water maze task. The two mouse lines did not differ in a non-spatial visible-platform version of the task. This hAPP-Yac/apoE-TR model may thus provide a useful tool to study the mechanisms involved in the antagonistic pleiotropic effects of APOE-varepsilon4 on cognitive functions. |
