| First Author | Suzuki Y | Year | 2002 |
| Journal | FEBS Lett | Volume | 521 |
| Issue | 1-3 | Pages | 67-71 |
| PubMed ID | 12067728 | Mgi Jnum | J:77286 |
| Mgi Id | MGI:2181313 | Doi | 10.1016/s0014-5793(02)02824-7 |
| Citation | Suzuki Y, et al. (2002) Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia. FEBS Lett 521(1-3):67-71 |
| abstractText | The gene encoding a transmembrane glycoprotein LIG-1, of which the extracellular region was organized with the leucine-rich repeats and immunoglobulin-like domains, was disrupted in mice by gene targeting. LIG-1-deficient mice developed a skin change on the tail and facial area after birth. The affected skin was histologically reminiscent of the epidermis in human common skin disease 'psoriasis'. LIG-1 was expressed in basal cells of the epidermis and outer root sheath cells of hair follicles in mice. Interestingly, the LIG-1 expression was apparently down-regulated in the psoriatic lesions, suggesting that LIG-1 inversely correlates with proliferative ability of epidermal keratinocytes. |
