| First Author | Bae SH | Year | 2014 |
| Journal | FEBS Lett | Volume | 588 |
| Issue | 1 | Pages | 86-91 |
| PubMed ID | 24291260 | Mgi Jnum | J:208073 |
| Mgi Id | MGI:5560862 | Doi | 10.1016/j.febslet.2013.11.010 |
| Citation | Bae SH, et al. (2014) Src regulates membrane trafficking of the Kv3.1b channel. FEBS Lett 588(1):86-91 |
| abstractText | The Kv3.1 channel plays a crucial role in regulating the high-frequency firing properties of neurons. Here, we determined whether Src regulates the subcellular distributions of the Kv3.1b channel. Co-expression of active Src induced a dramatic redistribution of Kv3.1b to the endoplasmic reticulum. Furthermore, co-expression of the Kv3.1b channel with active Src induced a remarkable decrease in the pool of Kv3.1b at the cell surface. Moreover, the co-expression of active Src results in a significant decrease in the peak current densities of the Kv3.1b channel, and a substantial alteration in the voltage dependence of its steady-state inactivation. Taken together, these results indicate that Src kinase may play an important role in regulating membrane trafficking of Kv3.1b channels. |
