|  Help  |  About  |  Contact Us

Protein Coding Gene : Zfpm2 zinc finger protein, multitype 2

Primary Identifier  MGI:1334444 Organism  mouse, laboratory
Chromosome  15 NCBI Gene Number  22762
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables transcription corepressor activity. Involved in several processes, including negative regulation of female gonad development; positive regulation of cardiac muscle cell proliferation; and positive regulation of male gonad development. Acts upstream of or within several processes, including circulatory system development; in utero embryonic development; and regulation of transcription by RNA polymerase II. Located in cytoplasm and male germ cell nucleus. Is expressed in several structures, including brain; embryo mesenchyme; genitourinary system; gut; and heart and pericardium. Used to study congenital diaphragmatic hernia; tetralogy of Fallot; and tricuspid atresia. Human ortholog(s) of this gene implicated in 46,XY sex reversal 9; congenital diaphragmatic hernia; myelodysplastic syndrome; and tetralogy of Fallot. Orthologous to human ZFPM2 (zinc finger protein, FOG family member 2).
PHENOTYPE: Homozygotes for targeted null mutations exhibit cardiac defects, including absence of coronary vasculature, resulting in lethality between E12.5 and E15.5. Conditional mutations reveal errors in ovary and testis development. [provided by MGI curators]
  • synonyms:
  • B330005D23Rik,
  • Zfpm2,
  • MGI:2444606,
  • FOG-2,
  • FOG2,
  • RIKEN cDNA B330005D23 gene,
  • zinc finger protein, multitype 2

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

3 Involved In Mutations

0 Strain

0 Transcripts

1 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

2 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For