| First Author | Maggio-Price L | Year | 1991 |
| Journal | Cell Immunol | Volume | 138 |
| Issue | 2 | Pages | 360-71 |
| PubMed ID | 1934076 | Mgi Jnum | J:1967 |
| Mgi Id | MGI:50491 | Doi | 10.1016/0008-8749(91)90160-d |
| Citation | Maggio-Price L, et al. (1991) Altered lymphocyte populations in sphha/sphha mice with chronic hemolytic anemia. Cell Immunol 138(2):360-71 |
| abstractText | Lymphocyte kinetics and phenotype were examined in mutant anemic sphha/sphha mice that manifest a lifelong lymphocytosis which accompanies their chronic hemolytic anemia. Anemic mice have significant increases in CD4+, CD8+, and sIgM+ lymphocytes in peripheral blood. Pulse and continuous infusion studies with [3H]TdR suggest that this apparent lymphoid expansion is not due to increased production of lymphocytes in bone marrow or thymus but rather to a redistribution of lymphocytes from the spleen to other peripheral lymphoid tissue sites as well as increased proliferation of T and B lymphocytes in lymph nodes. This murine model could be useful to examine lymphocyte perturbations that may accompany chronic hemolytic anemia in humans. |
