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Publication : Two differentially expressed interleukin-11 receptor genes in the mouse genome.

First Author  Bilinski P Year  1996
Journal  Biochem J Volume  320 ( Pt 2)
Pages  359-63 PubMed ID  8973540
Mgi Jnum  J:37144 Mgi Id  MGI:84572
Doi  10.1042/bj3200359 Citation  Bilinski P, et al. (1996) Two differentially expressed interleukin-11 receptor genes in the mouse genome. Biochem J 320(Pt 2):359-63
abstractText  Interleukin-ll (IL-11) is a multifunctional cytokine involved in the regulation of cell proliferation and differentiation in a variety of cell types and tissues in vitro and in vivo. The effects of IL-11 were shown to be mediated by the IL-11 receptor (hereafter referred to as IL-11R alpha), which is a ligand-binding subunit and provides ligand specificity in a functional multimeric signal-transduction complex with gp130. Here we show that the mouse genome contains a second gene encoding an IL-11- binding protein, referred to as IL-11R beta. The structure of the IL-11R beta gene is highly similar to that of IL- 11R alpha, and IL-11R beta exhibits 99% sequence identity with IL-11R alpha at the amino acid level. IL-11R beta is co-expressed with IL-11R alpha, albeit at lower levels, in embryos and in various adult tissues. IL-11R beta transcripts are abundant in testis, and, in contrast with IL-11R alpha, absent from skeletal muscle, IL-11R beta expressed in vitro binds IL-11 with high affinity, suggesting that the mouse genome contains a second functional IL-11R.
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