| First Author | Fuse S | Year | 2011 |
| Journal | Cell Immunol | Volume | 266 |
| Issue | 2 | Pages | 130-4 |
| PubMed ID | 21040905 | Mgi Jnum | J:167013 |
| Mgi Id | MGI:4866978 | Doi | 10.1016/j.cellimm.2010.09.008 |
| Citation | Fuse S, et al. (2011) Differential requirements for CD80/86-CD28 costimulation in primary and memory CD4 T cell responses to vaccinia virus. Cell Immunol 266(2):130-4 |
| abstractText | Vaccinia virus infection can confer immunity to smallpox by inducing potent T cell and antibody responses. While the CD8 T cell response to vaccinia virus has been well characterized, less is known about factors required for priming and memory for the CD4 T cells. Focusing on two recently described epitopes, we show that after intranasal infection, both I1L and L4R epitopes are co-dominant during the acute response, but the I1L epitope dominates during memory. CD4 T cell priming was intact in the absence of CD80/86, however secondary responses were reduced. This contrasts with our previous data showing CD80/86-CD28 interaction is required for optimal primary and memory CD8 T cell responses. The absence of CD80/86 also changed the immunodominance hierarchy during memory, with the I1L and L4R responses becoming co-dominant in knockout mice. These data highlight different costimulatory requirements for primary CD4 and CD8 T cell responses to vaccinia virus. |
