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Publication : Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate.

First Author  Wang L Year  2009
Journal  Cancer Cell Volume  16
Issue  4 Pages  336-46
PubMed ID  19800578 Mgi Jnum  J:153706
Mgi Id  MGI:4366128 Doi  10.1016/j.ccr.2009.08.016
Citation  Wang L, et al. (2009) Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate. Cancer Cell 16(4):336-46
abstractText  Despite clear epidemiological and genetic evidence for X-linked prostate cancer risk, all prostate cancer genes identified are autosomal. Here, we report somatic inactivating mutations and deletion of the X-linked FOXP3 gene residing at Xp11.23 in human prostate cancer. Lineage-specific ablation of FoxP3 in the mouse prostate epithelial cells leads to prostate hyperplasia and prostate intraepithelial neoplasia. In both normal and malignant prostate tissues, FOXP3 is both necessary and sufficient to transcriptionally repress cMYC, the most commonly overexpressed oncogene in prostate cancer as well as among the aggregates of other cancers. FOXP3 is an X-linked prostate tumor suppressor in the male. Because the male has only one X chromosome, our data represent a paradigm of 'single genetic hit' inactivation-mediated carcinogenesis.
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