| First Author | Chojnacka K | Year | 2015 |
| Journal | Mol Cell Endocrinol | Volume | 415 |
| Pages | 133-42 | PubMed ID | 26296907 |
| Mgi Jnum | J:228799 | Mgi Id | MGI:5749307 |
| Doi | 10.1016/j.mce.2015.08.012 | Citation | Chojnacka K, et al. (2015) The Src non-receptor tyrosine kinase paradigm: New insights into mammalian Sertoli cell biology. Mol Cell Endocrinol 415:133-42 |
| abstractText | Src kinases are non-receptor tyrosine kinases that phosphorylate diverse substrates, which control processes such as cell proliferation, differentiation and survival; cell adhesion; and cell motility. c-Src, the prototypical member of this protein family, is widely expressed by several organs that include the testis. In the seminiferous epithelium of the adult rat testis, c-Src is highest at the tubule lumen during the release of mature spermatids. Other studies show that testosterone regulates spermatid adhesion to Sertoli cells via c-Src, indicating Src phosphorylates key substrates that prompt the disassembly of Sertoli cell-spermatid junctions. A more recent in vitro study reveals that c-Src participates in the internalization of proteins that constitute the blood-testis barrier, which is present between Sertoli cells, suggesting a similar mechanism of junction disassembly is at play during spermiation. In this review, we discuss recent findings on c-Src, with an emphasis on its role in spermatogenesis in the mammalian testis. |
