| First Author | Kaneko Y | Year | 1997 |
| Journal | Biochem Biophys Res Commun | Volume | 233 |
| Issue | 1 | Pages | 113-6 |
| PubMed ID | 9144406 | Mgi Jnum | J:39675 |
| Mgi Id | MGI:87029 | Doi | 10.1006/bbrc.1997.6410 |
| Citation | Kaneko Y, et al. (1997) Developmentally regulated expression of APG-1, a member of heat shock protein 110 family in murine male germ cells. Biochem Biophys Res Commun 233(1):113-6 |
| abstractText | Apg-1 encodes a heat shock protein belonging to the heat shock protein 110 family, and is inducible by a 32 degrees C to 39 degrees C heat shock. Northern blot analysis of the testis from immature and adult mice, and of the purified germ cells revealed the quantitative change of the apg-1 transcripts during germ cell development. By in situ hybridization histochemistry the expressions of the apg-1 transcripts were detected in germ cells at specific stages of development including spermatocytes and spermatids. Although heat-induction of the apg-1 transcripts was observed in W/Wv mutant testis lacking germ cells, it was not detected in wild-type testis nor in the purified germ cells. Thus, the apg-1 expression is not heat-regulated but developmentally regulated in germ cells, suggesting that APG-1 plays a role in normal development of germ cells. |
