| First Author | Pászty C | Year | 1997 |
| Journal | Science | Volume | 278 |
| Issue | 5339 | Pages | 876-8 |
| PubMed ID | 9346488 | Mgi Jnum | J:44161 |
| Mgi Id | MGI:1099413 | Doi | 10.1126/science.278.5339.876 |
| Citation | Paszty C, et al. (1997) Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease [see comments]. Science 278(5339):876-8 |
| abstractText | To create mice expressing exclusively human sickle hemoglobin (HbS), transgenic mice expressing human alpha-, gamma-, and betaS-globin were generated and bred with knockout mice that had deletions of the murine alpha- and beta-globin genes. These sickle cell mice have the major features (irreversibly sickled red cells, anemia, multiorgan pathology) found in humans with sickle cell disease and, as such, represent a useful in vivo system to accelerate the development of improved therapies for this common genetic disease. |
