Primary Identifier | MGI:1289227 | Organism | mouse, laboratory |
Chromosome | 10 | NCBI Gene Number | 52696 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Involved in homologous chromosome orientation in meiotic metaphase I and regulation of meiosis I spindle assembly checkpoint. Located in kinetochore. Is expressed in several structures, including early conceptus; heart valve; nervous system; oocyte; and retina. Orthologous to human ZWINT (ZW10 interacting kinetochore protein). PHENOTYPE: Mice homozygous for a knock-out allele exhibit complete embryonic lethality between implantation and somite formation with inner cell mass and epiblast cells forming smaller outgrowth colonies. [provided by MGI curators] |