| Type | MGI:General | Description | basal Ba2+ influx into single smooth muscle cells is greatly elevated in cells from thoracic aortae or cerebral aerteries of mutant mice versus from wild-type littermates, and increases further upon application of a diacylglycerol (DAG) analog; infection by adenovirus expressing siRNA against Trpc3 mRNA significantly diminishes the basal Ba2+ flux in mutant smooth muscle cells, but has no effect in wild-type cells whole-cell patch clamp recording of cerebral artery smooth muscle cells demonstrates higher basal current densities and a more depolarized membrane potential in mutant than in wild-type cells |
