| First Author | Tatnell PJ | Year | 1998 |
| Journal | Biochim Biophys Acta | Volume | 1398 |
| Issue | 1 | Pages | 57-66 |
| PubMed ID | 9602058 | Mgi Jnum | J:48077 |
| Mgi Id | MGI:1261703 | Doi | 10.1016/s0167-4781(98)00028-1 |
| Citation | Tatnell PJ, et al. (1998) Mouse procathepsin E gene: molecular organisation and chromosomal localisation. Biochim Biophys Acta 1398(1):57-66 |
| abstractText | A 15.6 kb genomic clone encompassing the mouse procathepsin E gene was isolated and mapped. Sequencing revealed that the gene consists of nine exons followed by a polyadenylation signal at the 3'-end. The 5'-flanking region appears to be a TATA-less promoter but contains a nucleotide sequence that matches perfectly with the consensus motif of an initiator element [S.T. Smale, Biochim. Biophys. Acta 1351 (1997) 73-88.] to direct accurate initiation of transcription by RNA polymerase. This overlaps the site that was determined for the start of transcription. The absence of features considered typical of TATA-box regulated or housekeeping types of genes is consistent with the low levels of procathepsin E gene expression that are normally observed and might imply a unique sensitivity to or requirement for tissue-specific transcription factors that would account for the sporadic distribution of this aspartic proteinase in cells and tissues. The single copy of the procathepsin E gene was located on chromosome 1, near to that of mouse prorenin, a closely related aspartic proteinase involved in blood pressure regulation. Copyright 1998 Elsevier Science B.V. All rights reserved. |
