| First Author | Yamazaki K | Year | 1998 |
| Journal | Gene | Volume | 214 |
| Issue | 1-2 | Pages | 199-204 |
| PubMed ID | 9651528 | Mgi Jnum | J:49057 |
| Mgi Id | MGI:1276627 | Doi | 10.1016/s0378-1119(98)00202-9 |
| Citation | Yamazaki K, et al. (1998) Cloning of 5'-flanking region and a polymorphic CTT trinucleotide repeat within 5'-untranslated region of mouse R-type calcium channel alpha1-subunit (Cchra1) gene, and its genetic mapping. Gene 214(1-2):199-204 |
| abstractText | The 5'-flanking region of the mouse R-type calcium channel (Cchra1) gene was cloned, and a transcriptional start point (tsp) was determined by rapid amplification of 5'- cDNA end (5'RACE) method. The putative promoter region of the gene contained no obvious TATA or CCAAT element in the expected positions, but multiple putative binding sites for transcriptional factors, such as Spl, AP-1, AP-2, AP- 3, EGR-1, EGR-2, NF-kappa B and HIP1, were detected. We found the existence of a tandem CTT trinucleotide repeat within the 5'-untranslated region (UTR) of the gene, and its polymorphism between C57BL/6J and Mus spretus. Using this polymorphism, the Cchra1 was mapped to the region of chromosome 1 where the synteny to human chromosome Iq was conserved. (C) 1998 Elsevier Science B.V. All rights reserved. |
