| First Author | Eichelberger M | Year | 1991 |
| Journal | J Exp Med | Volume | 174 |
| Issue | 4 | Pages | 875-80 |
| PubMed ID | 1919440 | Mgi Jnum | J:110596 |
| Mgi Id | MGI:3640712 | Doi | 10.1084/jem.174.4.875 |
| Citation | Eichelberger M, et al. (1991) Clearance of influenza virus respiratory infection in mice lacking class I major histocompatibility complex-restricted CD8+ T cells. J Exp Med 174(4):875-80 |
| abstractText | Transgenic mice homozygous for a beta 2-microglobulin (beta 2-m) gene disruption and normal mice that had been treated with a CD8-specific mAb were infected intranasally with an H3N2 influenza A virus. Both groups of CD8T cell-deficient mice eliminated the virus from the infected respiratory tract. Potent CTL activity was detected in lung lavage populations taken from mice with intact CD8+ T cell function, with minimal levels of cytotoxicity being found for inflammatory cells obtained from the antibody-treated and beta 2-m mutant mice. We therefore conclude that cells infected with an influenza A virus can be cleared from the respiratory tract of mice lacking both functional class I major histocompatibility complex (MHC) glycoproteins and class I MHC-restricted, CD8+ effector T cells. |
