| First Author | Lin YY | Year | 2014 |
| Journal | Mol Cell Biol | Volume | 34 |
| Issue | 12 | Pages | 2339-49 |
| PubMed ID | 24732799 | Mgi Jnum | J:221624 |
| Mgi Id | MGI:5641146 | Doi | 10.1128/MCB.00042-14 |
| Citation | Lin YY, et al. (2014) KSRP and MicroRNA 145 are negative regulators of lipolysis in white adipose tissue. Mol Cell Biol 34(12):2339-49 |
| abstractText | White adipose tissue (WAT) releases fatty acids from stored triacylglycerol for an energy source. Here, we report that targeted deletion of KH-type splicing regulatory protein (KSRP), an RNA-binding protein that regulates gene expression at multiple levels, enhances lipolysis in epididymal WAT (eWAT) because of the upregulation of genes promoting lipolytic activity. Expression of microRNA 145 (miR-145) is decreased because of impaired primary miR-145 processing in Ksrp(-/-) eWAT. We show that miR-145 directly targets and represses Foxo1 and Cgi58, activators of lipolytic activity, and forced expression of miR-145 attenuates lipolysis. This study reveals a novel in vivo function of KSRP in controlling adipose lipolysis through posttranscriptional regulation of miR-145 expression. |
