| First Author | Galili N | Year | 1993 |
| Journal | Nat Genet | Volume | 5 |
| Issue | 3 | Pages | 230-5 |
| PubMed ID | 8275086 | Mgi Jnum | J:23759 |
| Mgi Id | MGI:71449 | Doi | 10.1038/ng1193-230 |
| Citation | Galili N, et al. (1993) Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma [published erratum appears in Nat Genet 1994 Feb;6(2):214]. Nat Genet 5(3):230-5 |
| abstractText | We have examined the structure and expression of the products associated with the t(2;13)(q35;q14) translocation associated with alveolar rhabdomyosarcoma. The chromosome 13 gene (FKHR) is identified as a member of the fork head domain family of transcription factors characterized by a conserved DNA binding motif. Polymerase chain reaction analysis demonstrates that a 5'PAX3-3' FKHR chimaeric transcript is expressed in all eight alveolar rhabdomyosarcomas investigated. Immunoprecipitation experiments detect the predicted fusion protein. These findings indicate that the t(2;13) generates a potentially tumorigenic fusion transcription factor consisting of intact PAX3 DNA binding domains, a truncated fork head DNA binding domain and C-terminal FKHR regions. |
