Primary Identifier | MGI:5432153 | Allele Type | Transgenic |
Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(YAC128)54Hay |
Strain of Origin | FVB/N | Is Recombinase | false |
Is Wild Type | false |
molecularNote | A YAC containing a full-length human huntingtin gene under the control of the endogenous human HDH promoter was modified with a 128 CAG repeat expansion. The resulting construct (YAC128) was used to generate transgenic mice. Founder line 54 had lower levels of protein expression compared to line 53 and 55. |