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Allele : Tg(Myh6*)140Lnwd transgene insertion 140, Leslie Leinwand

Primary Identifier  MGI:3793715 Allele Type  Transgenic
Attribute String  Inserted expressed sequence Gene  Tg(Myh6*)140Lnwd
Strain of Origin  (CBA x C57BL/6)F1 Is Recombinase  false
Is Wild Type  false
molecularNote  A rat myosin heavy chain promoter drives the expression of a rat cardiac alpha myosin heavy chain (Myh6) cDNA that was modified by mutating residue 1445 from a G to an A, and the deletion of codons 468-527. This resulted in a R403G substitution and a deletion in the putative actin binding domain in the encoded protein. This transgenic line exhibits a strong phenotype.
  • mutations:
  • Insertion
  • synonyms:
  • HCM,
  • HCM
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

1 Driven By

Trail: Allele

27 Publication categories

Trail: Allele